Risk Factors Associated with Default from Multi- and Extensively Drug-Resistant Tuberculosis Treatment, Uzbekistan: A Retrospective Cohort Analysis

ALT Sven Torfinn

Multi-drug resistant TB (MDR TB) is an infection for which at least two of the standard TB treatment drugs are not effective. Regimes to treat MDR TB are long, expensive, have many side effects and may be less successful.

In the MSF Uzbekistan TB programme 14% of patients between 2003 and 2006 defaulted and abandoned their treatment early. As the programme grew between 2007-2007, the authors report this rate rose to 24%, i.e. 1 in 4 patients defaulted. The risk of stopping treatment early was higher in those with more severely drug resistant infections, individuals who had defaulted before and patients over 45 years. The authors warn that expansion of any treatment programme needs to be accompanied by increased staffing and improved support for the patients, especially to those at risk of stopping treatment before fully cured.

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Authors: Maeve K. Lalor, Jane Greig, Sholpan Allamuratova1, Sandy Althomsons, Zinaida Tigay, Atadjan Khaemraev, Kai Braker, Oleksander Telnov, Philipp du Cros

Journal: Public Library of Science (PLoS) ONE

Keyword(s): Tuberculosis