Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999–2009
Artemisinin-based combination therapy (ACT) is the recommended first-line therapy for uncomplicated Plasmodium falciparum malaria worldwide but decreased artemisinin susceptibility, phenotypically characterized as slow parasite clearance time (PCT), has now been reported in Southeast Asia. This makes it all too important to measure the dynamics of parasite clearance in African patients treated with ACT over time, to understand trends and detect changes early enough to intervene.
Authors: Julien Zwang, Grant Dorsey, Andreas Mårtensson, Umberto d’Alessandro, Jean-Louis Ndiaye, Corine Karema, Abdoulaye Djimde, Philippe Brasseur, Sodiomon B Sirima and Piero Olliaro
Journal: Malaria Journal