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October 09,2001
Fatal Imbalance: The Crisis in Research and Development for Drugs for Neglected Diseases
Fatal Imbalance logo A report by the MSF Access to Essential Medicines Campaign and the Drugs for Neglected Diseases Working Group.
Report shows near empty pipeline of drugs for diseases of the world's poor

October 9, 2001, Geneva - Virtually no new drugs are being developed for diseases that predominantly affect the poor, according to "Fatal Imbalance", a report issued today by MSF.
Fatal Imbalance Press release

You can download the complete report,
including full page images (7.5mb),
in PDF format
here

A PDF version complete with text
but omitting full page images (516k)
here


Links to chapters and sections:

Executive summary

Chapter 1:
Whose health revolution?
  • What kind of needs does the pharmaceutical market cover?
  • Results of the DND/Harvard survey: Number of companies with research and development activities targetting drugs for neglected diseases

    Chapter 2:
    Dropped from the private research agenda
  • World drug market and world population compared region by region
  • Gaps in the drug development process

    Chapter 3:
    A matter of public responsibility
  • Estimates of public, nonprofit and foundation spending

    Chapter 4:
    What has been done so far to address the R&D crisis?
  • The International Conference on Harmonisation: Is the bar being raised too high?

    Recommendations for moving forward

    PROFILES:
    Teno: Profile of Teno, suffering from kala azar and about to have his twentieth injection for treatment.
    Bianga: Profile of Banga, suffering from sleeping sickness
    Lida: Profile of Lida, who has tuberculosis
    Pau: Profile of Pau suffering from malaria.

    MYTHS:
  • The typical cost of bringing a new drug to market is approximately US$500 million for research and development.

  • There is little investment in tropical diseases because there is weak patent protection in the countries most affected by these illnesses. After 2006, when all countries will have implemented TRIPS (international trade rules that mandate minimum 20-year patents), drugs will increase in developing countries.

  • If we introduce new medicines into poorer countries, we will accelerate the development of resistance. We don't necessarily need new drugs but we need to better use the ones we have.

    About this publication

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