Medical: Leishmaniasis (Kala Azar)
Kala azar attacks the immune system, causing fever, weight loss, anaemia and an enlarged spleen. There are considerable problems with existing diagnostic tests, which are either invasive or potentially dangerous and require lab facilities and specialists not readily available in resource-poor settings. Treatment requires painful, daily injections of drugs for 30 days. The drug most widely used to treat kala azar, sodium stibogluconate, was developed in the 1930s, is relatively expensive and causes a toxic reaction in some patients.
Co-infection of leishmaniasis and HIV is emerging as a growing threat, since both diseases attack and weaken the immune system. Infection with one of these diseases makes a person less resistant to the other and treatment becomes less effective.