HIV/AIDS treatment in developing countries: The battle for long-term survival has just begun
The public health approach to treatment in resource-limited settings has enabled significant scaling-up of treatment - thanks to fixed-dose combinations and to the lower prices of first generation treatments. But this approach has also come at the cost of compromise. For example, stavudine-containing regimens, no longer recommended in well-resourced settings because of side effects, are still widely used in resource-limited settings.
In addition, clinical algorithms and CD4 counts are still common methods to diagnose treatment failure even if these have proven to be unreliable.1,2 In most resource-poor settings, since viral monitoring is not available, patients and medical staff are only alerted to resistance when patients suffer from opportunistic infections. This is no longer acceptable medical practice.
It is now time to invest in improving the public health approach.
Treatment scale up must continue so that more people in need receive treatment and care. Support for universal access to treatment has been repeatedly confirmed by the international community.3 Clearly, the promise of universal access cannot be abandoned when only 30 percent of those in need have been reached.
At the same time, ambitions must be expanded for those already on treatment to increase their chances of long-term survival. If we do not respond to evolving medical practice with improvements in drugs and monitoring, we will be guilty of maintaining a sub-optimal status quo.
In-depth look at Khayelitsha, South Africa – five year results
Khayelitsha, home to 500,000 people, is a township located on the outskirts of Cape Town and has one of the highest HIV prevalence rates in South Africa. The country has the greatest number of people living with HIV/AIDS in the world. The majority of the population lives in informal housing and there are alarming rates of poverty, unemployment and crime, including sexual violence. Antenatal HIV prevalence stood at 22.0 percent in 2001, and at 32.7 percent in 2007.4
The TB incidence rate reached nearly 1,600 per 100,000 in 2006 and TB/HIV co-infection is nearly 70 percent.5
By the end of 2007, AIDS treatment was being provided in Khayelitsha as a routine government service, with limited support from Médecins Sans Frontières (MSF). Between 2001 to 2008, 12,000 people with HIV/AIDS started on ART. This is one of MSF’s longest running AIDS treatment projects.
The Khayelitsha AIDS treatment programme benefits from the relatively strong healthcare infrastructure in South Africa and has an extensive monitoring and data collection system.
Patients are prescribed either nevirapine (NVP) or efavirenz (EFV), with stavudine (d4T) and lamivudine (3TC) as a firstline regimen. A CD4 count is taken at the initiation of treatment and every six months thereafter. Viral load is done at six months and every six months after that.
An analysis of 7,323 people on ART from 2001-2007 shows relatively good long-term results. The cumulative estimate of mortality based on clinic-held data was 15.5 percent at five years.
Patients still on treatment were tested at one, three and five years, and found to be virologically suppressed at rates of 87.5 percent, 88.1 percent and 83.8 percent respectively. At five years, 16 percent of patients had thus failed first-line treatment.
Patients who switched to second-line treatment earlier were less likely to be virologically suppressed, with almost 25 percent failing at two years.
In this analysis, failure was defined as two viral load measurements above 5,000 copies per ml. The most common reasons for failure were treatment interruptions, exposure to nevirapine from prevention of mother-to-child transmission, and low baseline CD4 count. Of those failing virologically, fewer than 20 percent had a drop in CD4 count and would thus not have been detected by CD4 count alone.6
- 1 Calmy A, Ford N, Hirschel B et al. HIV Viral Load Monitoring in Resource-Limited Regions: Optional or Necessary? Clin Infect Dis 2007; 44(1): 128-34
- 2 Reynolds SJ, et al. Failure of immunological criteria to appropriately identify antiretroviral treatment failure in Uganda. AIDS 2009; 23 (6): 697-700
- 3 For instance at the UN General Assembly in 2001, and again at the G8 summit in 2005 in Gleneagles.
- 4 Western Cape Government Department of Health. Antenatal HIV and Syphilis Prevalence Survey, 2006.
- 5 MSF / City of Cape Town / Provincial Government of the Western Cape Department of Health: A patient-centred approach to drug-resistant tuberculosis treatment in the community:
a pilot project in Khayelitsha, South Africa, March 2009.
- 6 MSF internal data.